Neoadjuvant Imatinib Therapy for Dermatofibrosarcoma Protuberans
نویسندگان
چکیده
منابع مشابه
Imatinib in the treatment of dermatofibrosarcoma protuberans
Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with tendency to recur locally and only rarely metastasizes to vital organs. Surgery with wide margins remains the standard treatment. DFSP is characterized by specific chromosomal abnormalities involving the platelet derived growth factor B locus (PDGFB). In the majority of cases a supernumerary ring chromosome containing amplified ...
متن کاملRecurrent dermatofibrosarcoma protuberans treated with neoadjuvant imatinib mesylate followed by Mohs micrographic surgery
DFSP: Dermatofibrosarcoma protuberans INTRODUCTION Dermatofibrosarcoma protuberans (DFSP) is an uncommon, soft tissue sarcoma of mesenchymal origin characterized by its slow, infiltrative growth pattern and high risk of local recurrence after standard surgical excision. We describe a young man with a recurrent dermatofibrosarcoma protuberans after wide local excision treated with neoadjuvant im...
متن کاملDermatofibrosarcoma protuberans: from translocation to targeted therapy
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery (MMS) are the preferred approaches for localized disease, while radiation...
متن کاملDermatofibrosarcoma protuberans.
Overview The NCCN Non-Melanoma Skin Cancer Panel has developed these guidelines outlining the treatment of dermatofibrosarcoma protuberans (DFSP) to supplement their other guidelines (NCCN Clinical Practice Guidelines in Oncology [NCCN Guidelines] for Basal Cell and Squamous Cell Skin Cancers and Merkel Cell Carcinoma; to view the most recent version of these guidelines, visit the NCCN Web site...
متن کاملTarget Therapy of Unresectable or Metastatic Dermatofibrosarcoma Protuberans With Imatinib Mesylate
Dermatofibrosarcoma protuberans (DFSP) is a rare, plaque-like tumor of the cutaneous tissue occurring more on the trunk than the extremities and neck. More than 95% of DFSP present anomalies on the 17q22 and 22q13 chromosomal regions leading to the fusion of COL1A1 and PDGFB genes. Surgery is the optimal treatment for DFSP, but less effective in locally advanced or metastatic patients, as is th...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2009
ISSN: 0003-987X
DOI: 10.1001/archdermatol.2009.140